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PDE10

cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; Isoform PDE10A2 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A; Isoform PDE10A1 of cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A

Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides (PubMed:10373451, PubMed:10393245, PubMed:16330539, PubMed:17389385, PubMed:27058447). Can hydrolyze both cAMP and cGMP, but has higher affinity for cAMP and is more efficient with cAMP as substrate (PubMed:10373451, PubMed:10393245, PubMed:17389385, PubMed:27058447). May play a critical role in regulating cAMP and cGMP levels in the striatum, a region of the brain that contributes to the control of movement and cognition (PubMed:27058447).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • PDE10A

    UniProt ID

    • Q9Y233
    • Q9Y233-2
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