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PBIR1

PPP2R1A-PPP2R2A-interacting phosphatase regulator 1

Acts as an inhibitor of serine/threonine-protein phosphatase 2A (PP2A) activity (PubMed:27588481, PubMed:33108758). Potentiates ubiquitin-mediated proteasomal degradation of serine/threonine-protein phosphatase 2A catalytic subunit alpha (PPP2CA) (PubMed:27588481). Inhibits PP2A-mediated dephosphorylation of WEE1, promoting ubiquitin-mediated proteolysis of WEE1, thereby releasing G2/M checkpoint (PubMed:33108758).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • PABIR1

    UniProt ID

    • Q96E09
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