PACER

Isoform 2 of Protein associated with UVRAG as autophagy enhancer;Protein associated with UVRAG as autophagy enhancer; Isoform 5 of Protein associated with UVRAG as autophagy enhancer; Isoform 6 of Protein associated with UVRAG as autophagy enhancer

Regulator of autophagy that promotes autophagosome maturation by facilitating the biogenesis of phosphatidylinositol 3-phosphate (PtdIns(3)P) in late steps of autophagy (PubMed:28306502, PubMed:30704899). Acts by antagonizing RUBCN, thereby stimulating phosphatidylinositol 3-kinase activity of the PI3K/PI3KC3 complex (PubMed:28306502). Following anchorage to the autophagosomal SNARE STX17, promotes the recruitment of PI3K/PI3KC3 and HOPS complexes to the autophagosome to regulate the fusion specificity of autophagosomes with late endosomes/lysosomes (PubMed:28306502). Binds phosphoinositides phosphatidylinositol 3-phosphate (PtdIns(3)P), 4-phosphate (PtdIns(4)P) and 5-phosphate (PtdIns(5)P) (PubMed:28306502). In addition to its role in autophagy, acts as a regulator of lipid and glycogen homeostasis (By similarity). May act as a tumor suppressor (Probable).

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • RUBCNL

UniProt ID

  • Q9H714
  • Q9H714-4
  • Q9H714-6
Off-the-shelf

Request the PACER Assay

Tell us a little more about your study so we can optimize the assay for your specific needs.

"*" indicates required fields

This field is for validation purposes and should be left unchanged.