NUMB

Protein numb homolog; Isoform 2 of Protein numb homolog; Isoform 3 of Protein numb homolog; Isoform 4 of Protein numb homolog;Protein numb homolog

Regulates clathrin-mediated receptor endocytosis (PubMed:18657069). Plays a role in the process of neurogenesis (By similarity). Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate (By similarity). Not required for the proliferation of neural progenitor cells before the onset of neurogenesis. Also involved postnatally in the subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity (By similarity). May also mediate local repair of brain ventricular wall damage (By similarity).

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • NUMB

UniProt ID

  • P49757
  • P49757-3
  • P49757-4

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