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NSUN5

Isoform 2 of 28S rRNA (cytosine-C(5))-methyltransferase;28S rRNA (cytosine-C(5))-methyltransferase; Isoform 2 of 28S rRNA (cytosine-C(5))-methyltransferase; Isoform 4 of 28S rRNA (cytosine-C(5))-methyltransferase

S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C(5) position of cytosine 3782 (m5C3782) in 28S rRNA (PubMed:23913415, PubMed:31428936, PubMed:31722427). m5C3782 promotes protein translation without affecting ribosome biogenesis and fidelity (PubMed:31428936, PubMed:31722427). Required for corpus callosum and cerebral cortex development (By similarity).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • NSUN5

    UniProt ID

    • Q96P11
    • Q96P11-2
    • Q96P11-4
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