NSF1C

Isoform 3 of NSFL1 cofactor p47;NSFL1 cofactor p47;NSFL1 cofactor p47

Reduces the ATPase activity of VCP (By similarity). Necessary for the fragmentation of Golgi stacks during mitosis and for VCP-mediated reassembly of Golgi stacks after mitosis (By similarity). May play a role in VCP-mediated formation of transitional endoplasmic reticulum (tER) (By similarity). Inhibits the activity of CTSL (in vitro) (PubMed:15498563). Together with UBXN2B/p37, regulates the centrosomal levels of kinase AURKA/Aurora A during mitotic progression by promoting AURKA removal from centrosomes in prophase (PubMed:23649807). Also, regulates spindle orientation during mitosis (PubMed:23649807).

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • NSFL1C

UniProt ID

  • Q9UNZ2

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