NRBF2

Nuclear receptor-binding factor 2; Isoform 2 of Nuclear receptor-binding factor 2

May modulate transcriptional activation by target nuclear receptors. Can act as transcriptional activator (in vitro). ; Involved in starvation-induced autophagy probably by its association with PI3K complex I (PI3KC3-C1). However, effects has been described variably. Involved in the induction of starvation-induced autophagy (PubMed:24785657). Stabilzes PI3KC3-C1 assembly and enhances ATG14-linked lipid kinase activity of PIK3C3 (By similarity). Proposed to negatively regulate basal and starvation-induced autophagy and to inhibit PIK3C3 activity by modulating interactions in PI3KC3-C1 (PubMed:25086043). May be involved in autophagosome biogenesis (PubMed:25086043). May play a role in neural progenitor cell survival during differentiation (By similarity).

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • NRBF2

UniProt ID

  • Q96F24

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