NIT1

Deaminated glutathione amidase;Isoform 1 of Deaminated glutathione amidase; Isoform 1 of Deaminated glutathione amidase; Isoform 5 of Deaminated glutathione amidase;Deaminated glutathione amidase; Isoform 4 of Deaminated glutathione amidase

Catalyzes the hydrolysis of the amide bond in N-(4-oxoglutarate)-L-cysteinylglycine (deaminated glutathione), a metabolite repair reaction to dispose of the harmful deaminated glutathione. Plays a role in cell growth and apoptosis: loss of expression promotes cell growth, resistance to DNA damage stress and increased incidence to NMBA-induced tumors. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells.

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • NIT1

UniProt ID

  • Q86X76
  • Q86X76-2
  • Q86X76-3
  • Q86X76-4

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