NCOR2

Isoform 4 of Nuclear receptor corepressor 2;Nuclear receptor corepressor 2; Isoform 3 of Nuclear receptor corepressor 2

Transcriptional corepressor (PubMed:20812024). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 4 have different affinities for different nuclear receptors. Involved in the regulation BCL6-dependent of the germinal center (GC) reactions, mainly through the control of the GC B-cells proliferation and survival. Recruited by ZBTB7A to the androgen response elements/ARE on target genes, negatively regulates androgen receptor signaling and androgen-induced cell proliferation (PubMed:20812024).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • NCOR2

UniProt ID

  • Q9Y618
  • Q9Y618-5

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