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MTU1

Mitochondrial tRNA-specific 2-thiouridylase 1

Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • TRMU

    UniProt ID

    • O75648
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