MTCL2

Microtubule cross-linking factor 2; Isoform 2 of Microtubule cross-linking factor 2

Microtubule-associated factor that enables integration of the centrosomal and Golgi-associated microtubules on the Golgi membrane, supporting directional migration. Preferentially acts on the perinuclear microtubules accumulated around the Golgi. Associates with the Golgi membrane through the N-terminal coiled-coil region and directly binds microtubules through the C-terminal domain (By similarity). Required for faithful chromosome segregation during mitosis (PubMed:33587225). Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner (By similarity).

    Matrix Type

    • Plasma
    • Tissue/Cells

    Gene Symbol

    • MTCL2

    UniProt ID

    • O94964

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