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MIB2

Isoform 6 of E3 ubiquitin-protein ligase MIB2; Isoform 3 of E3 ubiquitin-protein ligase MIB2;E3 ubiquitin-protein ligase MIB2; Isoform 4 of E3 ubiquitin-protein ligase MIB2

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • MIB2

UniProt ID

  • Q96AX9
  • Q96AX9-4
  • Q96AX9-6
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