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MIB2

Isoform 6 of E3 ubiquitin-protein ligase MIB2; Isoform 3 of E3 ubiquitin-protein ligase MIB2;E3 ubiquitin-protein ligase MIB2; Isoform 4 of E3 ubiquitin-protein ligase MIB2

E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors.

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