MGAP

MAX gene-associated protein; Isoform 2 of MAX gene-associated protein

Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5′-AATTTCACACCTAGGTGTGAAATT-3′ core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor (By similarity).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • MGA

UniProt ID

  • Q8IWI9

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