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MET2A

tRNA N(3)-methylcytidine methyltransferase METTL2A

S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767, PubMed:34268557). N(3)-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:34268557).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • METTL2A

    UniProt ID

    • Q96IZ6
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