MDHC

Malate dehydrogenase, cytoplasmic; Isoform 3 of Malate dehydrogenase, cytoplasmic;Malate dehydrogenase, cytoplasmic; Isoform 2 of Malate dehydrogenase, cytoplasmic

Catalyzes the reduction of aromatic alpha-keto acids in the presence of NADH (PubMed:2449162, PubMed:3052244). Plays essential roles in the malate-aspartate shuttle and the tricarboxylic acid cycle, important in mitochondrial NADH supply for oxidative phosphorylation (PubMed:31538237). Catalyzes the reduction of 2-oxoglutarate to 2-hydroxyglutarate, leading to elevated reactive oxygen species (ROS) (PubMed:34012073).

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • MDH1

UniProt ID

  • P40925
  • P40925-3

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