MBD1

Isoform 10 of Methyl-CpG-binding domain protein 1; Isoform 8 of Methyl-CpG-binding domain protein 1; Isoform 9 of Methyl-CpG-binding domain protein 1; Isoform 12 of Methyl-CpG-binding domain protein 1; Isoform 2 of Methyl-CpG-binding domain protein 1;Methyl-CpG-binding domain protein 1; Isoform 5 of Methyl-CpG-binding domain protein 1; Isoform 2 of Methyl-CpG-binding domain protein 1;Isoform 12 of Methyl-CpG-binding domain protein 1

Transcriptional repressor that binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binding is abolished by the presence of 7-mG that is produced by DNA damage by methylmethanesulfonate (MMS). Acts as transcriptional repressor and plays a role in gene silencing by recruiting ATF7IP, which in turn recruits factors such as the histone methyltransferase SETDB1. Probably forms a complex with SETDB1 and ATF7IP that represses transcription and couples DNA methylation and histone ‘Lys-9’ trimethylation. Isoform 1 and isoform 2 can also repress transcription from unmethylated promoters.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • MBD1

UniProt ID

  • Q9UIS9
  • Q9UIS9-12
  • Q9UIS9-2
  • Q9UIS9-5
  • Q9UIS9-8
  • Q9UIS9-9

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