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LTBP4

Isoform 3 of Latent-transforming growth factor beta-binding protein 4; Isoform 2 of Latent-transforming growth factor beta-binding protein 4;Latent-transforming growth factor beta-binding protein 4;Latent-transforming growth factor beta-binding protein 4;Isoform 2 of Latent-transforming growth factor beta-binding protein 4

Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta.

Associated with:

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • LTBP4

UniProt ID

  • Q8N2S1
  • Q8N2S1-2
  • Q8N2S1-3
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