LRRF1

Leucine-rich repeat flightless-interacting protein 1;Isoform 4 of Leucine-rich repeat flightless-interacting protein 1; Isoform 2 of Leucine-rich repeat flightless-interacting protein 1; Isoform 3 of Leucine-rich repeat flightless-interacting protein 1;Leucine-rich repeat flightless-interacting protein 1

Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5′-AGCCCCCGGCG-3′) and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • LRRFIP1

UniProt ID

  • Q32MZ4
  • Q32MZ4-3
  • Q32MZ4-4

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