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LIMC1

LIM and calponin homology domains-containing protein 1; Isoform 10 of LIM and calponin homology domains-containing protein 1; Isoform 2 of LIM and calponin homology domains-containing protein 1

Actin stress fibers-associated protein that activates non-muscle myosin IIa. Activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. Through the activation of non-muscle myosin IIa, positively regulates actin stress fibers assembly and stabilizes focal adhesions. It therefore negatively regulates cell spreading and cell migration.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • LIMCH1

    UniProt ID

    • Q9UPQ0
    • Q9UPQ0-2
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