KMT2C

Histone-lysine N-methyltransferase 2C; Isoform 2 of Histone-lysine N-methyltransferase 2C; Isoform 3 of Histone-lysine N-methyltransferase 2C

Histone methyltransferase that catalyzes methyl group transfer from S-adenosyl-L-methionine to the epsilon-amino group of ‘Lys-4’ of histone H3 (H3K4) (PubMed:25561738). Part of chromatin remodeling machinery predominantly forms H3K4me1 methylation marks at active chromatin sites where transcription and DNA repair take place (PubMed:22266653, PubMed:24081332, PubMed:25561738). Likely plays a redundant role with KMT2D in enriching H3K4me1 mark on primed and active enhancer elements (PubMed:24081332).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • KMT2C

UniProt ID

  • Q8NEZ4
  • Q8NEZ4-3

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