Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin.

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • KLKB1

UniProt ID

  • P03952

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