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KITM

Thymidine kinase 2, mitochondrial; Isoform 6 of Thymidine kinase 2, mitochondrial; Isoform 2 of Thymidine kinase 2, mitochondrial

Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix (PubMed:11687801, PubMed:9989599). In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK (PubMed:9989599). Widely used as target of antiviral and chemotherapeutic agents (PubMed:9989599).

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • TK2

UniProt ID

  • O00142
  • O00142-6
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