KI67

Proliferation marker protein Ki-67;Isoform Short of Proliferation marker protein Ki-67

Required to maintain individual mitotic chromosomes dispersed in the cytoplasm following nuclear envelope disassembly (PubMed:27362226). Associates with the surface of the mitotic chromosome, the perichromosomal layer, and covers a substantial fraction of the chromosome surface (PubMed:27362226). Prevents chromosomes from collapsing into a single chromatin mass by forming a steric and electrostatic charge barrier: the protein has a high net electrical charge and acts as a surfactant, dispersing chromosomes and enabling independent chromosome motility (PubMed:27362226). Binds DNA, with a preference for supercoiled DNA and AT-rich DNA (PubMed:10878551). Does not contribute to the internal structure of mitotic chromosomes (By similarity). May play a role in chromatin organization (PubMed:24867636). It is however unclear whether it plays a direct role in chromatin organization or whether it is an indirect consequence of its function in maintaining mitotic chromosomes dispersed (Probable).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • MKI67

UniProt ID

  • P46013
  • P46013-2

Request the KI67 Assay

Tell us a little more about your study so we can optimize the assay for your specific needs.

"*" indicates required fields

This field is for validation purposes and should be left unchanged.