KI13A

Kinesin-like protein KIF13A; Isoform 4 of Kinesin-like protein KIF13A; Isoform 2 of Kinesin-like protein KIF13A; Isoform 3 of Kinesin-like protein KIF13A

Plus end-directed microtubule-dependent motor protein involved in intracellular transport and regulating various processes such as mannose-6-phosphate receptor (M6PR) transport to the plasma membrane, endosomal sorting during melanosome biogenesis and cytokinesis. Mediates the transport of M6PR-containing vesicles from trans-Golgi network to the plasma membrane via direct interaction with the AP-1 complex. During melanosome maturation, required for delivering melanogenic enzymes from recycling endosomes to nascent melanosomes by creating peripheral recycling endosomal subdomains in melanocytes. Also required for the abcission step in cytokinesis: mediates translocation of ZFYVE26, and possibly TTC19, to the midbody during cytokinesis.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • KIF13A

    UniProt ID

    • Q9H1H9
    • Q9H1H9-3
    • Q9H1H9-4

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