ITA6

Isoform Alpha-6X1A of Integrin alpha-6; Isoform Alpha-6X2A of Integrin alpha-6; Isoform Alpha-6X1B of Integrin alpha-6;Integrin alpha-6; Isoform 9 of Integrin alpha-6; Isoform Alpha-6X2B of Integrin alpha-6; Isoform Alpha-6X1X2A of Integrin alpha-6;Integrin alpha-6; Isoform Alpha-6X2A of Integrin alpha-6; Isoform Alpha-6X1X2A of Integrin alpha-6;Isoform Alpha-6X1A of Integrin alpha-6; Isoform 9 of Integrin alpha-6

Integrin alpha-6/beta-1 (ITGA6:ITGB1) is a receptor for laminin on platelets (By similarity). Integrin alpha-6/beta-1 (ITGA6:ITGB1) is present in oocytes and is involved in sperm-egg fusion (By similarity). Integrin alpha-6/beta-4 (ITGA6:ITGB4) is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity). ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778). ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760). ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464).

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • ITGA6

UniProt ID

  • P23229
  • P23229-2
  • P23229-3
  • P23229-4
  • P23229-5
  • P23229-6
  • P23229-9

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