IST1

IST1 homolog;IST1 homolog; Isoform 5 of IST1 homolog; Isoform 2 of IST1 homolog; Isoform 4 of IST1 homolog;Isoform 2 of IST1 homolog

ESCRT-III-like protein involved in cytokinesis, nuclear envelope reassembly and endosomal tubulation (PubMed:19129479, PubMed:26040712, PubMed:28242692). Is required for efficient abscission during cytokinesis (PubMed:19129479). Involved in recruiting VPS4A and/or VPS4B to the midbody of dividing cells (PubMed:19129479, PubMed:19129480). During late anaphase, involved in nuclear envelope reassembly and mitotic spindle disassembly together with the ESCRT-III complex: IST1 acts by mediating the recruitment of SPAST to the nuclear membrane, leading to microtubule severing (PubMed:26040712). Recruited to the reforming nuclear envelope (NE) during anaphase by LEMD2 (PubMed:28242692). Regulates early endosomal tubulation together with the ESCRT-III complex by mediating the recruitment of SPAST (PubMed:23897888).

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • IST1

UniProt ID

  • P53990
  • P53990-2
  • P53990-4
  • P53990-5

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