HPS1

BLOC-3 complex member HPS1; Isoform II of BLOC-3 complex member HPS1; Isoform IV of BLOC-3 complex member HPS1; Isoform III of BLOC-3 complex member HPS1

Component of the BLOC-3 complex, a complex that acts as a guanine exchange factor (GEF) for RAB32 and RAB38, promotes the exchange of GDP to GTP, converting them from an inactive GDP-bound form into an active GTP-bound form. The BLOC-3 complex plays an important role in the control of melanin production and melanosome biogenesis and promotes the membrane localization of RAB32 and RAB38 (PubMed:23084991).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • HPS1

    UniProt ID

    • Q92902
    • Q92902-3
    • Q92902-4

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