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HMCS2

Hydroxymethylglutaryl-CoA synthase, mitochondrial; Isoform 2 of Hydroxymethylglutaryl-CoA synthase, mitochondrial

Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • HMGCS2

UniProt ID

  • P54868
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