Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate, a precursor for cholesterol synthesis.

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • HMGCS1

UniProt ID

  • Q01581

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