Methyltransferase that adds a 2′-O-methyl group at the 3′-end of piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. This probably protects the 3′-end of piRNAs from uridylation activity and subsequent degradation. Stabilization of piRNAs is essential for gametogenesis.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • HENMT1

    UniProt ID

    • Q5T8I9

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