Can degrade highly structured RNAs through its concerted ATP-dependent RNA helicase and 3′ to 5′ exoribonuclease activities (PubMed:37602378). Shows a strong preference for pyrimidine over purine residues for its nuclease activity (PubMed:37602378). Acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA (PubMed:16239304, PubMed:23525231).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • HELZ2

UniProt ID

  • Q9BYK8

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