GTF2I

General transcription factor II-I; Isoform 4 of General transcription factor II-I; Isoform 2 of General transcription factor II-I; Isoform 3 of General transcription factor II-I

Interacts with the basal transcription machinery by coordinating the formation of a multiprotein complex at the C-FOS promoter, and linking specific signal responsive activator complexes. Promotes the formation of stable high-order complexes of SRF and PHOX1 and interacts cooperatively with PHOX1 to promote serum-inducible transcription of a reporter gene deriven by the C-FOS serum response element (SRE). Acts as a coregulator for USF1 by binding independently two promoter elements, a pyrimidine-rich initiator (Inr) and an upstream E-box. Required for the formation of functional ARID3A DNA-binding complexes and for activation of immunoglobulin heavy-chain transcription upon B-lymphocyte activation.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • GTF2I

UniProt ID

  • P78347
  • P78347-3
  • P78347-4

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