GGT5

Isoform 3 of Glutathione hydrolase 5 proenzyme;Glutathione hydrolase 5 proenzyme; Isoform 2 of Glutathione hydrolase 5 proenzyme

Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione-S-conjugate such as leukotriene C4 (PubMed:21447318). Does not cleaves gamma-glutamyl compounds such as gamma-glutamyl leucine (PubMed:21447318). May also catalyze a transpeptidation reaction in addition to the hydrolysis reaction, transferring the gamma-glutamyl moiety to an acceptor amino acid to form a new gamma-glutamyl compound (PubMed:21447318). Acts as a negative regulator of geranylgeranyl glutathione bioactivity by cleaving off its gamma-glutamyl group, playing a role in adaptive immune responses (PubMed:30842656).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • GGT5

UniProt ID

  • P36269
  • P36269-3

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