Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed (PubMed:19666512). Plays a role in ciliogenesis (PubMed:20393563).

Associated with:

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • GSN

UniProt ID

  • P06396
  • P06396-2
  • P06396-3

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