FXL12

Isoform 2 of F-box/LRR-repeat protein 12;F-box/LRR-repeat protein 12

Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia.

Associated with:

Protein Ubiquitination

Matrix Type

Tissue/Cells

Gene Symbol

FBXL12

UniProt ID

Q9NXK8

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FXL12

Isoform 2 of F-box/LRR-repeat protein 12;F-box/LRR-repeat protein 12

Associated with:

Matrix Type

Gene Symbol

UniProt ID

Request the FXL12 Assay

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