FLII

Protein flightless-1 homolog;Isoform 2 of Protein flightless-1 homolog

Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments (By similarity). It also plays a role in the assembly of cardiomyocyte cell adhesion complexes (By similarity). Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation (By similarity). May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1 (PubMed:14966289). Involved in estrogen hormone signaling.

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • FLII

UniProt ID

  • Q13045
  • Q13045-2

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