FCHO1

Isoform 3 of F-BAR domain only protein 1;F-BAR domain only protein 1; Isoform 2 of F-BAR domain only protein 1

Functions in an early step of clathrin-mediated endocytosis (PubMed:30822429). Has both a membrane binding/bending activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. May regulate Bmp signaling by regulating clathrin-mediated endocytosis of Bmp receptors. Involved in the regulation of T-cell poliferation and activation (PubMed:30822429, PubMed:32098969). Affects TCR clustering upon receptor triggering and modulates its internalisation, playing a role in TCR-dependent T-cell activation (PubMed:32098969).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • FCHO1

UniProt ID

  • O14526
  • O14526-3

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