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FAP20

Fanconi anemia core complex-associated protein 20; Isoform 4 of Fanconi anemia core complex-associated protein 20; Isoform 5 of Fanconi anemia core complex-associated protein 20; Isoform 3 of Fanconi anemia core complex-associated protein 20; Isoform 2 of Fanconi anemia core complex-associated protein 20

Component of the Fanconi anemia (FA) complex required to recruit the FA complex to DNA interstrand cross-links (ICLs) and promote ICLs repair. Following DNA damage recognizes and binds ‘Lys-63’-linked ubiquitin generated by RNF8 at ICLs and recruits other components of the FA complex. Promotes translesion synthesis via interaction with REV1.

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • FAAP20

UniProt ID

  • Q6NZ36
  • Q6NZ36-3
  • Q6NZ36-4
  • Q6NZ36-5
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