ESRP2

Isoform 2 of Epithelial splicing regulatory protein 2;Epithelial splicing regulatory protein 2

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2.

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • ESRP2

UniProt ID

  • Q9H6T0

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