ESRP1

Epithelial splicing regulatory protein 1; Isoform 4 of Epithelial splicing regulatory protein 1; Isoform 3 of Epithelial splicing regulatory protein 1; Isoform 5 of Epithelial splicing regulatory protein 1; Isoform 2 of Epithelial splicing regulatory protein 1

mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (PubMed:19285943). Regulates splicing and expression of genes involved in inner ear development, auditory hair cell differentiation, and cell fate specification in the cochlear epithelium (By similarity).

Matrix Type

  • Tissue/Cells

Gene Symbol

  • ESRP1

UniProt ID

  • Q6NXG1
  • Q6NXG1-3
  • Q6NXG1-4
  • Q6NXG1-5

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