EPG5

Ectopic P granules protein 5 homolog; Isoform 2 of Ectopic P granules protein 5 homolog

Involved in autophagy. May play a role in a late step of autophagy, such as clearance of autophagosomal cargo. Plays a key role in innate and adaptive immune response triggered by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides from pathogens, and mediated by the nucleotide-sensing receptor TLR9. It is necessary for the translocation of CpG dinucleotides from early endosomes to late endosomes and lysosomes, where TLR9 is located (PubMed:29130391).

Associated with:

Matrix Type

  • Tissue/Cells

Gene Symbol

  • EPG5

UniProt ID

  • Q9HCE0

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