EHF

ETS homologous factor; Isoform 3 of ETS homologous factor; Isoform 2 of ETS homologous factor

Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • EHF

UniProt ID

  • Q9NZC4
  • Q9NZC4-3

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