DGKB

Diacylglycerol kinase beta; Isoform 2 of Diacylglycerol kinase beta

Diacylglycerol kinase that converts diacylglycerol/DAG into phosphatidic acid/phosphatidate/PA and regulates the respective levels of these two bioactive lipids (PubMed:11719522). Thereby, acts as a central switch between the signaling pathways activated by these second messengers with different cellular targets and opposite effects in numerous biological processes (Probable). Has a higher activity with long-chain diacylglycerols like 1,2-di-(9Z-octadecenoyl)-sn-glycerol compared to 1,2-didecanoyl-sn-glycerol (By similarity). Specifically expressed in brain, it regulates neuron-specific morphological changes including neurite branching and neurite spine formation (By similarity). ; [Isoform 2]: Does not associate with membranes but has a diacylglycerol kinase activity.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • DGKB

UniProt ID

  • Q9Y6T7

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