DCTN2

Dynactin subunit 2; Isoform 2 of Dynactin subunit 2;Dynactin subunit 2; Isoform 3 of Dynactin subunit 2

Part of the dynactin complex that activates the molecular motor dynein for ultra-processive transport along microtubules. In the dynactin soulder domain, binds the ACTR1A filament and acts as a molecular ruler to determine the length (By similarity). Modulates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtubules to centrosomes. May play a role in synapse formation during brain development (By similarity).

Associated with:

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • DCTN2

UniProt ID

  • Q13561
  • Q13561-3

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