CYAC3

Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3; Isoform 2 of Lysosomal membrane ascorbate-dependent ferrireductase CYB561A3

Transmembrane reductase that uses ascorbate as an electron donor in the cytoplasm and transfers electrons across membranes to reduce iron cations Fe(3+) into Fe(2+) in the lumen of the late endosome and lysosome. Reduced iron can then be extruded from the late endosome and lysosome to the cytoplasm by divalent metal-specific transporters. It is therefore most probably involved in endosomal and lysosomal cellular iron homeostasis.

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • CYB561A3

    UniProt ID

    • Q8NBI2

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