S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2′-O-ribose methylation to the 5′-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway.

Matrix Type

  • Tissue/Cells

Gene Symbol

  • CMTR1

UniProt ID

  • Q8N1G2

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