CLCN4

Isoform 2 of H(+)/Cl(-) exchange transporter 4;H(+)/Cl(-) exchange transporter 4

Strongly outwardly rectifying, electrogenic H(+)/Cl(-)exchanger which mediates the exchange of chloride ions against protons (PubMed:18063579, PubMed:23647072, PubMed:25644381, PubMed:27550844, PubMed:28972156). The CLC channel family contains both chloride channels and proton-coupled anion transporters that exchange chloride or another anion for protons (PubMed:29845874). The presence of conserved gating glutamate residues is typical for family members that function as antiporters (PubMed:29845874).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • CLCN4

    UniProt ID

    • P51793

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