CD59

CD59 glycoprotein;CD59 glycoprotein; Isoform 2 of CD59 glycoprotein

Potent inhibitor of the complement membrane attack complex (MAC) action. Acts by binding to the C8 and/or C9 complements of the assembling MAC, thereby preventing incorporation of the multiple copies of C9 required for complete formation of the osmolytic pore. This inhibitor appears to be species-specific. Involved in signal transduction for T-cell activation complexed to a protein tyrosine kinase.; The soluble form from urine retains its specific complement binding activity, but exhibits greatly reduced ability to inhibit MAC assembly on cell membranes.

Associated with:

Matrix Type

  • Plasma
  • Tissue/Cells

Gene Symbol

  • CD59

UniProt ID

  • P13987

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