CBAR1

Isoform 3 of CBY1-interacting BAR domain-containing protein 1;CBY1-interacting BAR domain-containing protein 1; Isoform 4 of CBY1-interacting BAR domain-containing protein 1; Isoform 2 of CBY1-interacting BAR domain-containing protein 1

Acts as a positive regulator of ciliary hedgehog signaling (By similarity). Probable regulator of ciliogenesis involved in limb morphogenesis (PubMed:27528616, PubMed:30395363). In cooperation with CBY1 it is involved in the recruitment and fusion of endosomal vesicles at distal appendages during early stages of ciliogenesis (PubMed:27528616, PubMed:30395363). Plays an important role in the mitochondrial function and is essential for maintaining mitochondrial morphology and inner membrane ultrastructure (PubMed:30404948). In vitro, can generate membrane curvature through preferential interaction with negatively charged phospholipids such as phosphatidylinositol 4,5-bisphosphate and cardiolipin and hence orchestrate cristae shape (PubMed:30404948).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • CIBAR1

    UniProt ID

    • A1XBS5
    • A1XBS5-3
    • A1XBS5-4

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