Cap-specific adenosine methyltransferase that catalyzes formation of N(6),2′-O-dimethyladenosine cap (m6A(m)) by methylating the adenosine at the second transcribed position of capped mRNAs (PubMed:30467178, PubMed:30487554, PubMed:31279658, PubMed:31279659, PubMed:33428944). Recruited to the early elongation complex of RNA polymerase II (RNAPII) via interaction with POLR2A and mediates formation of m6A(m) co-transcriptionally (PubMed:30467178).

    Matrix Type

    • Tissue/Cells

    Gene Symbol

    • PCIF1

    UniProt ID

    • Q9H4Z3

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